1r1m

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{{STRUCTURE_1r1m| PDB=1r1m | SCENE= }}
{{STRUCTURE_1r1m| PDB=1r1m | SCENE= }}
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'''Structure of the OmpA-like domain of RmpM from Neisseria meningitidis'''
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===Structure of the OmpA-like domain of RmpM from Neisseria meningitidis===
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==Overview==
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RmpM is a putative peptidoglycan binding protein from Neisseria meningitidis that has been shown to interact with integral outer membrane proteins such as porins and TonB-dependent transporters. Here we report the 1.9 A crystal structure of the C-terminal domain of RmpM. The 150-residue domain adopts a betaalphabetaalphabetabeta fold, as first identified in Bacillus subtilis chorismate mutase. The C-terminal RmpM domain is homologous to the periplasmic, C-terminal domain of Escherichia coli OmpA; these domains are thought to be responsible for non-covalent interactions with peptidoglycan. From the structure of the OmpA-like domain of RmpM, we suggest a putative peptidoglycan binding site and identify residues that may be essential for binding. Both the crystal structure and solution experiments indicate that RmpM may exist as a dimer. This would promote more efficient peptidoglycan binding, by allowing RmpM to interact simultaneously with two glycan chains through its C-terminal, OmpA-like binding domain, while its (structurally uncharacterized) N-terminal domain could stabilize oligomers of porins and TonB-dependent transporters in the outer membrane.
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{{ABSTRACT_PUBMED_14763978}}
==About this Structure==
==About this Structure==
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[[Category: Grizot, S.]]
[[Category: Grizot, S.]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:57:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:29:26 2008''

Revision as of 07:29, 28 July 2008

Image:1r1m.png

Template:STRUCTURE 1r1m

Structure of the OmpA-like domain of RmpM from Neisseria meningitidis

Template:ABSTRACT PUBMED 14763978

About this Structure

1R1M is a Single protein structure of sequence from Neisseria meningitidis. Full crystallographic information is available from OCA.

Reference

Structure of the OmpA-like domain of RmpM from Neisseria meningitidis., Grizot S, Buchanan SK, Mol Microbiol. 2004 Feb;51(4):1027-37. PMID:14763978

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