2ftu

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[[Image:2ftu.gif|left|200px]]
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{{STRUCTURE_2ftu| PDB=2ftu | SCENE= }}
{{STRUCTURE_2ftu| PDB=2ftu | SCENE= }}
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'''solution structure of domain 3 of RAP'''
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===solution structure of domain 3 of RAP===
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==Overview==
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The receptor associated protein (RAP) is an antagonist and molecular chaperone that binds tightly to low-density lipoprotein receptor family members in the endoplasmic reticulum (ER). After escorting these receptors to the Golgi, RAP dissociates from the receptors. The molecular mechanism of the dissociation has been unknown until now. The solution structure of RAP-D3 domain presented here reveals a striking increase in positively charged residues on the surface of this RAP domain due to protonation of solvent-exposed histidine sidechains as the pH is reduced from a near neutral pH of the ER to the acidic pH of the Golgi. Structure-based mutagenesis studies in vitro and in cells confirm that the protonation of histidine residues as a consequence of the pH changes modulate the binding/release of RAP from LRP. This histidine switch may serve as a general mechanism for regulating cell trafficking events.
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(as it appears on PubMed at http://www.pubmed.gov), where 16678114 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16678114}}
==About this Structure==
==About this Structure==
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2FTU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTU OCA].
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2FTU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTU OCA].
==Reference==
==Reference==
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[[Category: Rap]]
[[Category: Rap]]
[[Category: Receptor-associated protein]]
[[Category: Receptor-associated protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:18:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:32:24 2008''

Revision as of 07:32, 28 July 2008

Image:2ftu.png

Template:STRUCTURE 2ftu

solution structure of domain 3 of RAP

Template:ABSTRACT PUBMED 16678114

About this Structure

2FTU is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi., Lee D, Walsh JD, Mikhailenko I, Yu P, Migliorini M, Wu Y, Krueger S, Curtis JE, Harris B, Lockett S, Blacklow SC, Strickland DK, Wang YX, Mol Cell. 2006 May 5;22(3):423-30. PMID:16678114

Page seeded by OCA on Mon Jul 28 10:32:24 2008

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