1pnn

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[[Image:1pnn.gif|left|200px]]
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{{STRUCTURE_1pnn| PDB=1pnn | SCENE= }}
{{STRUCTURE_1pnn| PDB=1pnn | SCENE= }}
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'''PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA'''
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===PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA===
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==Overview==
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The crystal structure of a nucleic acid triplex reveals a helix, designated P-form, that differs from previously reported nucleic acid structures. The triplex consists of one polypurine DNA strand complexed to a polypyrimidine hairpin peptide nucleic acid (PNA) and was successfully designed to promote Watson-Crick and Hoogsteen base pairing. The P-form helix is underwound, with a base tilt similar to B-form DNA. The bases are displaced from the helix axis even more than in A-form DNA. Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 2:1 PNA-DNA complexes. This structure expands the number of known stable helical forms that nucleic acids can adopt.
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(as it appears on PubMed at http://www.pubmed.gov), where 8525381 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8525381}}
==About this Structure==
==About this Structure==
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[[Category: Hairpin pna:dna triplex]]
[[Category: Hairpin pna:dna triplex]]
[[Category: Triplex watson-crick hoogsteen]]
[[Category: Triplex watson-crick hoogsteen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:17:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:36:13 2008''

Revision as of 07:36, 28 July 2008

Image:1pnn.png

Template:STRUCTURE 1pnn

PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA

Template:ABSTRACT PUBMED 8525381

About this Structure

Full crystallographic information is available from OCA.

Reference

A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:8525381

Page seeded by OCA on Mon Jul 28 10:36:13 2008

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