2qi2

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{{STRUCTURE_2qi2| PDB=2qi2 | SCENE= }}
{{STRUCTURE_2qi2| PDB=2qi2 | SCENE= }}
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'''Crystal structure of the Thermoplasma acidophilum Pelota protein'''
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===Crystal structure of the Thermoplasma acidophilum Pelota protein===
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==Overview==
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The yeast protein Dom34 is a key component of no-go decay, by which mRNAs with translational stalls are endonucleolytically cleaved and subsequently degraded. However, the identity of the endoribonuclease is unknown. Homologs of Dom34, called Pelota, are broadly conserved in eukaryotes and archaea. To gain insights into the structure and function of Dom34/Pelota, we have determined the structure of Pelota from Thermoplasma acidophilum (Ta Pelota) and investigated the ribonuclease activity of Dom34/Pelota. The structure of Ta Pelota is tripartite, and its domain 1 has the RNA-binding Sm fold. We have discovered that Ta Pelota has a ribonuclease activity and that its domain 1 is sufficient for the catalytic activity. We also demonstrate that domain 1 of Dom34 has an endoribonuclease activity against defined RNA substrates containing a stem loop, which supports a direct catalytic role of yeast Dom34 in no-go mRNA decay.
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(as it appears on PubMed at http://www.pubmed.gov), where 17889667 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17889667}}
==About this Structure==
==About this Structure==
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[[Category: Dom34]]
[[Category: Dom34]]
[[Category: Pelota]]
[[Category: Pelota]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:00:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:38:32 2008''

Revision as of 07:38, 28 July 2008

Image:2qi2.png

Template:STRUCTURE 2qi2

Crystal structure of the Thermoplasma acidophilum Pelota protein

Template:ABSTRACT PUBMED 17889667

About this Structure

2QI2 is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Structural and functional insights into Dom34, a key component of no-go mRNA decay., Lee HH, Kim YS, Kim KH, Heo I, Kim SK, Kim O, Kim HK, Yoon JY, Kim HS, Kim do J, Lee SJ, Yoon HJ, Kim SJ, Lee BG, Song HK, Kim VN, Park CM, Suh SW, Mol Cell. 2007 Sep 21;27(6):938-50. PMID:17889667

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