1sz9

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[[Image:1sz9.gif|left|200px]]
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{{STRUCTURE_1sz9| PDB=1sz9 | SCENE= }}
{{STRUCTURE_1sz9| PDB=1sz9 | SCENE= }}
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'''The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model'''
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===The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model===
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==Overview==
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During transcription, RNA polymerase (Pol) II synthesizes eukaryotic messenger RNA. Transcription is coupled to RNA processing by the carboxy-terminal domain (CTD) of Pol II, which consists of up to 52 repeats of the sequence Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7 (refs 1, 2). After phosphorylation, the CTD binds tightly to a conserved CTD-interacting domain (CID) present in the proteins Pcf11 and Nrd1, which are essential and evolutionarily conserved factors for polyadenylation-dependent and -independent 3'-RNA processing, respectively. Here we describe the structure of a Ser 2-phosphorylated CTD peptide bound to the CID domain of Pcf11. The CTD motif Ser 2-Pro 3-Thr 4-Ser 5 forms a beta-turn that binds to a conserved groove in the CID domain. The Ser 2 phosphate group does not make direct contact with the CID domain, but may be recognized indirectly because it stabilizes the beta-turn with an additional hydrogen bond. Iteration of the peptide structure results in a compact beta-spiral model of the CTD. The model suggests that, during the mRNA transcription-processing cycle, compact spiral regions in the CTD are unravelled and regenerated in a phosphorylation-dependent manner.
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(as it appears on PubMed at http://www.pubmed.gov), where 15241417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15241417}}
==About this Structure==
==About this Structure==
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[[Category: Pcf11]]
[[Category: Pcf11]]
[[Category: Rna polymerase ii ctd interacting domain]]
[[Category: Rna polymerase ii ctd interacting domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:18:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:38:54 2008''

Revision as of 07:38, 28 July 2008

Image:1sz9.png

Template:STRUCTURE 1sz9

The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model

Template:ABSTRACT PUBMED 15241417

About this Structure

1SZ9 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors., Meinhart A, Cramer P, Nature. 2004 Jul 8;430(6996):223-6. PMID:15241417

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