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2d46

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[[Image:2d46.gif|left|200px]]
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{{STRUCTURE_2d46| PDB=2d46 | SCENE= }}
{{STRUCTURE_2d46| PDB=2d46 | SCENE= }}
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'''Solution Structure of the Human Beta4a-A Domain'''
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===Solution Structure of the Human Beta4a-A Domain===
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==Overview==
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Ca2+ channel beta subunits regulate trafficking and gating (opening and closing) of voltage-dependent Ca2+ channel alpha1 subunits. Based on primary sequence comparisons, they are thought to be modular structures composed of five domains (A-E) that are related to the large family of membrane associated guanylate-kinase (MAGUK) proteins. The crystal structures of the beta subunit core, B-D, domains have recently been reported; however, very little is known about the structures of the A and E domains. The N-terminal A domain is a hypervariable region that differs among the four subtypes of Ca2+ channel beta subunits (beta1-beta4). Furthermore, this domain undergoes alternative splicing to create multiple N-terminal structures within a given gene class that have distinct effects on gating. We have solved the solution structure of the A domain of the human beta4a subunit, a splice variant that we have shown previously to have alpha1 subunit subtype-specific effects on Ca2+ channel trafficking and gating.
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(as it appears on PubMed at http://www.pubmed.gov), where 16385006 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16385006}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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2D46 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D46 OCA].
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2D46 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D46 OCA].
==Reference==
==Reference==
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[[Category: Nuclear magnetic resonance]]
[[Category: Nuclear magnetic resonance]]
[[Category: Protein structure]]
[[Category: Protein structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:40:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:40:52 2008''

Revision as of 07:40, 28 July 2008

Image:2d46.png

Template:STRUCTURE 2d46

Contents

Solution Structure of the Human Beta4a-A Domain

Template:ABSTRACT PUBMED 16385006

Disease

Known disease associated with this structure: Epilepsy, generalized idiopathic OMIM:[601949], Epilepsy, juvenile myoclonic OMIM:[601949], Episodic ataxia, type 5 OMIM:[601949]

About this Structure

2D46 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the N-terminal A domain of the human voltage-gated Ca2+channel beta4a subunit., Vendel AC, Rithner CD, Lyons BA, Horne WA, Protein Sci. 2006 Feb;15(2):378-83. Epub 2005 Dec 29. PMID:16385006

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