2jms

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{{STRUCTURE_2jms| PDB=2jms | SCENE= }}
{{STRUCTURE_2jms| PDB=2jms | SCENE= }}
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'''NMR Structure of En-6 pheromone from the Antarctic Ciliate Euplotes nobilii'''
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===NMR Structure of En-6 pheromone from the Antarctic Ciliate Euplotes nobilii===
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==Overview==
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Ciliates of Euplotes species constitutively secrete pleiotropic protein pheromones, which are capable to function as prototypic autocrine growth factors as well as paracrine inducers of mating processes. This paper reports the amino acid sequence and the NMR structure of the pheromone En-6 isolated from the antarctic species Euplotes nobilii. The 63-residue En-6 polypeptide chain forms three alpha-helices in positions 18-25, 36-40 and 46-56, which are arranged in an up-down-up three-helix bundle forming the edges of a distorted trigonal pyramid. The base of the pyramid is covered by the N-terminal heptadecapeptide segment, which includes a 3(10)-turn of residues 3-6. This topology is covalently anchored by four long-range disulfide bonds. Comparison with the smaller pheromones of E. raikovi, a closely related species living in temperate waters, shows that the two-pheromone families have the same three-helix bundle architecture. It then appears that cold-adaptation of the En proteins is primarily related to increased lengths of the chain-terminal peptide segments and the surface-exposed loops connecting the regular secondary structures, and to the presence of solvent-exposed clusters of negatively charged side-chains.
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{{ABSTRACT_PUBMED_17663000}}
==About this Structure==
==About this Structure==
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2JMS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Euplotes_nobilii Euplotes nobilii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMS OCA].
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2JMS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Euplotes_nobilii Euplotes nobilii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMS OCA].
==Reference==
==Reference==
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[[Category: Protein]]
[[Category: Protein]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:40:53 2008''

Revision as of 07:40, 28 July 2008

Image:2jms.png

Template:STRUCTURE 2jms

NMR Structure of En-6 pheromone from the Antarctic Ciliate Euplotes nobilii

Template:ABSTRACT PUBMED 17663000

About this Structure

2JMS is a Single protein structure of sequence from Euplotes nobilii. Full experimental information is available from OCA.

Reference

Cold-adaptation in sea-water-borne signal proteins: sequence and NMR structure of the pheromone En-6 from the Antarctic ciliate Euplotes nobilii., Pedrini B, Placzek WJ, Koculi E, Alimenti C, LaTerza A, Luporini P, Wuthrich K, J Mol Biol. 2007 Sep 14;372(2):277-86. Epub 2007 Jun 26. PMID:17663000

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