1qxk

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[[Image:1qxk.gif|left|200px]]
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{{Seed}}
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[[Image:1qxk.png|left|200px]]
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{{STRUCTURE_1qxk| PDB=1qxk | SCENE= }}
{{STRUCTURE_1qxk| PDB=1qxk | SCENE= }}
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'''Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B'''
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===Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B===
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==Overview==
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Monoacid-based PTP1B inhibitors with improved physiochemical properties have been investigated. A (2-hydroxy-phenoxy) acetic acid-based phosphotyrosyl mimetic has been linked with an optimized second arylphosphate binding site ligand to produce compound 20 with low micromolar potency against PTP1B, good selectivity over TCPTP (20-fold) and high cell permeability in the Caco-2 system.
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The line below this paragraph, {{ABSTRACT_PUBMED_14592481}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14592481 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14592481}}
==About this Structure==
==About this Structure==
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[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Ptp1b monoacid-based and cell permeable]]
[[Category: Ptp1b monoacid-based and cell permeable]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:49:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:42:23 2008''

Revision as of 07:42, 28 July 2008

Image:1qxk.png

Template:STRUCTURE 1qxk

Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B

Template:ABSTRACT PUBMED 14592481

About this Structure

1QXK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B., Xin Z, Liu G, Abad-Zapatero C, Pei Z, Szczepankiewicz BG, Li X, Zhang T, Hutchins CW, Hajduk PJ, Ballaron SJ, Stashko MA, Lubben TH, Trevillyan JM, Jirousek MR, Bioorg Med Chem Lett. 2003 Nov 17;13(22):3947-50. PMID:14592481

Page seeded by OCA on Mon Jul 28 10:42:23 2008

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