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1o0d

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[[Image:1o0d.jpg|left|200px]]
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{{Seed}}
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[[Image:1o0d.png|left|200px]]
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{{STRUCTURE_1o0d| PDB=1o0d | SCENE= }}
{{STRUCTURE_1o0d| PDB=1o0d | SCENE= }}
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'''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor'''
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===Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor===
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==Overview==
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Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_12781189}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12781189 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12781189}}
==Disease==
==Disease==
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[[Category: Ternary complex]]
[[Category: Ternary complex]]
[[Category: Thrombin/active-site inhibitor/exo-site inhibitor]]
[[Category: Thrombin/active-site inhibitor/exo-site inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:12:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:45:50 2008''

Revision as of 07:45, 28 July 2008

Image:1o0d.png

Template:STRUCTURE 1o0d

Contents

Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor

Template:ABSTRACT PUBMED 12781189

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1O0D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189

Page seeded by OCA on Mon Jul 28 10:45:50 2008

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