2jfu

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{{Seed}}
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{{STRUCTURE_2jfu| PDB=2jfu | SCENE= }}
{{STRUCTURE_2jfu| PDB=2jfu | SCENE= }}
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'''CRYSTAL STRUCTURE OF ENTEROCOCCUS FAECIUM GLUTAMATE RACEMASE IN COMPLEX WITH PHOSPHATE'''
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===CRYSTAL STRUCTURE OF ENTEROCOCCUS FAECIUM GLUTAMATE RACEMASE IN COMPLEX WITH PHOSPHATE===
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==Overview==
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Glutamate racemase is an enzyme essential to the bacterial cell wall biosynthesis pathway, and has therefore been considered as a target for antibacterial drug discovery. We characterized the glutamate racemases of several pathogenic bacteria using structural and biochemical approaches. Here we describe three distinct mechanisms of regulation for the family of glutamate racemases: allosteric activation by metabolic precursors, kinetic regulation through substrate inhibition, and D-glutamate recycling using a d-amino acid transaminase. In a search for selective inhibitors, we identified a series of uncompetitive inhibitors specifically targeting Helicobacter pylori glutamate racemase that bind to a cryptic allosteric site, and used these inhibitors to probe the mechanistic and dynamic features of the enzyme. These structural, kinetic and mutational studies provide insight into the physiological regulation of these essential enzymes and provide a basis for designing narrow-spectrum antimicrobial agents.
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(as it appears on PubMed at http://www.pubmed.gov), where 17568739 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17568739}}
==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Peptidoglycan biosynthesis]]
[[Category: Peptidoglycan biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:51:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:46:11 2008''

Revision as of 07:46, 28 July 2008

Image:2jfu.png

Template:STRUCTURE 2jfu

CRYSTAL STRUCTURE OF ENTEROCOCCUS FAECIUM GLUTAMATE RACEMASE IN COMPLEX WITH PHOSPHATE

Template:ABSTRACT PUBMED 17568739

About this Structure

2JFU is a Single protein structure of sequence from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

Exploitation of structural and regulatory diversity in glutamate racemases., Lundqvist T, Fisher SL, Kern G, Folmer RH, Xue Y, Newton DT, Keating TA, Alm RA, de Jonge BL, Nature. 2007 Jun 14;447(7146):817-22. PMID:17568739

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