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1zap

From Proteopedia

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[[Image:1zap.gif|left|200px]]
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{{Seed}}
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[[Image:1zap.png|left|200px]]
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{{STRUCTURE_1zap| PDB=1zap | SCENE= }}
{{STRUCTURE_1zap| PDB=1zap | SCENE= }}
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'''SECRETED ASPARTIC PROTEASE FROM C. ALBICANS'''
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===SECRETED ASPARTIC PROTEASE FROM C. ALBICANS===
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==Overview==
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The three-dimensional structure of a secreted aspartic protease from Candida albicans complexed with a potent inhibitor reveals variations on the classical aspartic protease theme that dramatically alter the specificity of this class of enzymes. The structure presents: (1) an 8-residue insertion near the first disulfide (Cys 45-Cys 50, pepsin numbering) that results in a broad flap extending toward the active site; (2) a 7-residue deletion replacing helix hN2 (Ser 110-Tyr 114), which enlarges the S3 pocket; (3) a short polar connection between the two rigid body domains that alters their relative orientation and provides certain specificity; and (4) an ordered 11-residue addition at the carboxy terminus. The inhibitor binds in an extended conformation and presents a branched structure at the P3 position. The implications of these findings for the design of potent antifungal agents are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 8845753 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8845753}}
==About this Structure==
==About this Structure==
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[[Category: Candida albican]]
[[Category: Candida albican]]
[[Category: Secreted]]
[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:23:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:48:45 2008''

Revision as of 07:48, 28 July 2008

Image:1zap.png

Template:STRUCTURE 1zap

SECRETED ASPARTIC PROTEASE FROM C. ALBICANS

Template:ABSTRACT PUBMED 8845753

About this Structure

1ZAP is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.

Reference

Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents., Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Stewart K, Navaza J, Payne CD, Ray TL, Protein Sci. 1996 Apr;5(4):640-52. PMID:8845753

Page seeded by OCA on Mon Jul 28 10:48:45 2008

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