1n3h

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{{STRUCTURE_1n3h| PDB=1n3h | SCENE= }}
{{STRUCTURE_1n3h| PDB=1n3h | SCENE= }}
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'''Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc'''
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===Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc===
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==Overview==
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The notion that certain proteins lack intrinsic globular structure under physiological conditions and that the attainment of fully folded structure only occurs upon the binding of target molecules has been recently gaining popularity. We report here the solution structure of the PTB domain of the signaling protein Shc in the free form. Comparison of this structure with that of the complex form, obtained previously with a phosphopeptide ligand, reveals that the Shc PTB domain is structurally disordered in the free form, particularly around the regions constituting the peptide binding pocket. The binding of the ligand appears to reorganize this pocket through local folding events triggering a conformational switch between the free and the complex forms.
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{{ABSTRACT_PUBMED_12906822}}
==About this Structure==
==About this Structure==
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1N3H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3H OCA].
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1N3H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3H OCA].
==Reference==
==Reference==
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[[Category: Beta sandwich]]
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[[Category: Free protein]]
[[Category: Free protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:02:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:49:29 2008''

Revision as of 07:49, 28 July 2008

Image:1n3h.png

Template:STRUCTURE 1n3h

Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc

Template:ABSTRACT PUBMED 12906822

About this Structure

1N3H is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Coupling of folding and binding in the PTB domain of the signaling protein Shc., Farooq A, Zeng L, Yan KS, Ravichandran KS, Zhou MM, Structure. 2003 Aug;11(8):905-13. PMID:12906822

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