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354d

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{{STRUCTURE_354d| PDB=354d | SCENE= }}
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'''STRUCTURE OF LOOP E FROM E. COLI 5S RRNA'''
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===STRUCTURE OF LOOP E FROM E. COLI 5S RRNA===
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==Overview==
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Two new RNA structures portray how non-Watson-Crick base pairs and metal ions can produce a unique RNA shape suitable for recognition by proteins. The crystal structures of a 62 nt domain of E. coli 5S ribosomal RNA and a duplex dodecamer encompassing an internal loop E have been determined at 3.0 and 1.5 A, respectively. This loop E region is distorted by three "cross-strand purine stacks" and three novel, water-mediated noncanonical base pairs and stabilized by a four metal ion zipper. These features give its minor groove a unique hydrogen-bonding surface and make the adjacent major groove wide enough to permit recognition by the ribosomal protein L25, which is expected to bind to this surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 9393863 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9393863}}
==About this Structure==
==About this Structure==
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[[Category: Overhanging base]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:16:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:57:07 2008''

Revision as of 07:57, 28 July 2008

Image:354d.png

Template:STRUCTURE 354d

STRUCTURE OF LOOP E FROM E. COLI 5S RRNA

Template:ABSTRACT PUBMED 9393863

About this Structure

Full crystallographic information is available from OCA.

Reference

Metals, motifs, and recognition in the crystal structure of a 5S rRNA domain., Correll CC, Freeborn B, Moore PB, Steitz TA, Cell. 1997 Nov 28;91(5):705-12. PMID:9393863

Page seeded by OCA on Mon Jul 28 10:57:07 2008

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