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2img

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{{STRUCTURE_2img| PDB=2img | SCENE= }}
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'''Crystal structure of dual specificity protein phosphatase 23 from Homo sapiens in complex with ligand malate ion'''
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===Crystal structure of dual specificity protein phosphatase 23 from Homo sapiens in complex with ligand malate ion===
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==Overview==
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The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
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(as it appears on PubMed at http://www.pubmed.gov), where 18058037 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18058037}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Vhz]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:39:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:57:37 2008''

Revision as of 07:57, 28 July 2008

Image:2img.png

Template:STRUCTURE 2img

Crystal structure of dual specificity protein phosphatase 23 from Homo sapiens in complex with ligand malate ion

Template:ABSTRACT PUBMED 18058037

About this Structure

2IMG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037

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