2nq2

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[[Image:2nq2.gif|left|200px]]
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{{STRUCTURE_2nq2| PDB=2nq2 | SCENE= }}
{{STRUCTURE_2nq2| PDB=2nq2 | SCENE= }}
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'''An inward-facing conformation of a putative metal-chelate type ABC transporter.'''
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===An inward-facing conformation of a putative metal-chelate type ABC transporter.===
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==Overview==
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The crystal structure of a putative metal-chelate-type adenosine triphosphate (ATP)-binding cassette (ABC) transporter encoded by genes HI1470 and HI1471 of Haemophilus influenzae has been solved at 2.4 angstrom resolution. The permeation pathway exhibits an inward-facing conformation, in contrast to the outward-facing state previously observed for the homologous vitamin B12 importer BtuCD. Although the structures of both HI1470/1 and BtuCD have been solved in nucleotide-free states, the pairs of ABC subunits in these two structures differ by a translational shift in the plane of the membrane that coincides with a repositioning of the membrane-spanning subunits. The differences observed between these ABC transporters involve relatively modest rearrangements and may serve as structural models for inward- and outward-facing conformations relevant to the alternating access mechanism of substrate translocation.
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(as it appears on PubMed at http://www.pubmed.gov), where 17158291 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17158291}}
==About this Structure==
==About this Structure==
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[[Category: Putative iron chelatin abc transporter]]
[[Category: Putative iron chelatin abc transporter]]
[[Category: Transmembrane domain]]
[[Category: Transmembrane domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:46:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:02:00 2008''

Revision as of 08:02, 28 July 2008

Image:2nq2.png

Template:STRUCTURE 2nq2

An inward-facing conformation of a putative metal-chelate type ABC transporter.

Template:ABSTRACT PUBMED 17158291

About this Structure

2NQ2 is a Protein complex structure of sequences from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

An inward-facing conformation of a putative metal-chelate-type ABC transporter., Pinkett HW, Lee AT, Lum P, Locher KP, Rees DC, Science. 2007 Jan 19;315(5810):373-7. Epub 2006 Dec 7. PMID:17158291

Page seeded by OCA on Mon Jul 28 11:02:00 2008

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