2o3v

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[[Image:2o3v.gif|left|200px]]
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{{STRUCTURE_2o3v| PDB=2o3v | SCENE= }}
{{STRUCTURE_2o3v| PDB=2o3v | SCENE= }}
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'''Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33'''
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===Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33===
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==Overview==
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The lack of absolute prokaryotic selectivity of natural antibiotics is widespread and is a significant clinical problem. The use of this disadvantage of aminoglycoside antibiotics for the possible treatment of human genetic diseases is extremely challenging. Here, we have used a combination of biochemical and structural analysis to compare and contrast the molecular mechanisms of action and the structure-activity relationships of a new synthetic aminoglycoside, NB33, and a structurally similar natural aminoglycoside apramycin. The data presented herein demonstrate the general molecular principles that determine the decreased selectivity of apramycin for the prokaryotic decoding site, and the increased selectivity of NB33 for the eukaryotic decoding site. These results are therefore extremely beneficial for further research on both the design of new aminoglycoside-based antibiotics with diminished deleterious effects on humans, as well as the design of new aminoglycoside-based structures that selectively target the eukaryotic ribosome.
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{{ABSTRACT_PUBMED_17705310}}
==About this Structure==
==About this Structure==
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[[Category: Stop codon readthrough]]
[[Category: Stop codon readthrough]]
[[Category: Translation inhibition]]
[[Category: Translation inhibition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:17:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:02:31 2008''

Revision as of 08:02, 28 July 2008

Image:2o3v.png

Template:STRUCTURE 2o3v

Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33

Template:ABSTRACT PUBMED 17705310

About this Structure

2O3V is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites., Kondo J, Hainrichson M, Nudelman I, Shallom-Shezifi D, Barbieri CM, Pilch DS, Westhof E, Baasov T, Chembiochem. 2007 Sep 24;8(14):1700-9. PMID:17705310

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