2qxf

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[[Image:2qxf.jpg|left|200px]]
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{{Seed}}
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[[Image:2qxf.png|left|200px]]
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{{STRUCTURE_2qxf| PDB=2qxf | SCENE= }}
{{STRUCTURE_2qxf| PDB=2qxf | SCENE= }}
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'''Product bound structure of exonuclease I at 1.5 angstrom resolution'''
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===Product bound structure of exonuclease I at 1.5 angstrom resolution===
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==Overview==
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In Escherichia coli, exonuclease I (ExoI) is a monomeric processive 3'-5' exonuclease that degrades single-stranded DNA. The enzyme has been implicated as primarily being involved in repairing frameshift mutations. The structure of the enzyme has previously been determined in a hexagonal space group at 2.4 A resolution. Here, the structure of ExoI in complex with a nucleotide product, thymidine 5'-monophosphate, is described in an orthorhombic space group at 1.5 A resolution. This new high-resolution structure provides some insight into the interactions involved in binding a nucleotide product. The conserved active site contains a unique metal-binding position when compared with orthologous sites in the Klenow fragment, T4 DNA polymerase and dnaQ. This unique difference is proposed to be a consequence of the repositioning of an important histidine, His181, away from the active site.
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The line below this paragraph, {{ABSTRACT_PUBMED_18219121}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18219121 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18219121}}
==About this Structure==
==About this Structure==
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[[Category: Product bound structure]]
[[Category: Product bound structure]]
[[Category: Sh3-like domain]]
[[Category: Sh3-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:56:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:04:46 2008''

Revision as of 08:04, 28 July 2008

Image:2qxf.png

Template:STRUCTURE 2qxf

Product bound structure of exonuclease I at 1.5 angstrom resolution

Template:ABSTRACT PUBMED 18219121

About this Structure

2QXF is a Single protein structure of sequence from Escherichia coli k12. Full crystallographic information is available from OCA.

Reference

Structure of Escherichia coli exonuclease I in complex with thymidine 5'-monophosphate., Busam RD, Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):206-10. Epub 2008, Jan 16. PMID:18219121

Page seeded by OCA on Mon Jul 28 11:04:46 2008

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