2vp0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2vp0", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:2vp0.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2vp0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2vp0| PDB=2vp0 | SCENE= }}
{{STRUCTURE_2vp0| PDB=2vp0 | SCENE= }}
-
'''STRUCTURAL STUDIES OF NUCLEOSIDE ANALOG AND FEEDBACK INHIBITOR BINDING TO DROSOPHILA MELANOGASTER MULTISUBSTRATE DEOXYRIBONUCLEOSIDE KINASE'''
+
===STRUCTURAL STUDIES OF NUCLEOSIDE ANALOG AND FEEDBACK INHIBITOR BINDING TO DROSOPHILA MELANOGASTER MULTISUBSTRATE DEOXYRIBONUCLEOSIDE KINASE===
-
==Overview==
+
<!--
-
The Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (dNK; EC 2.7.1.145) has a high turnover rate and a wide substrate range that makes it a very good candidate for gene therapy. This concept is based on introducing a suicide gene into malignant cells in order to activate a prodrug that eventually may kill the cell. To be able to optimize the function of dNK, it is vital to have structural information of dNK complexes. In this study we present crystal structures of dNK complexed with four different nucleoside analogs (floxuridine, brivudine, zidovudine and zalcitabine) and relate them to the binding of substrate and feedback inhibitors. dCTP and dGTP bind with the base in the substrate site, similarly to the binding of the feedback inhibitor dTTP. All nucleoside analogs investigated bound in a manner similar to that of the pyrimidine substrates, with many interactions in common. In contrast, the base of dGTP adopted a syn-conformation to adapt to the available space of the active site.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18384378}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18384378 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18384378}}
==About this Structure==
==About this Structure==
Line 38: Line 42:
[[Category: Salvage pathway]]
[[Category: Salvage pathway]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:25:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:06:58 2008''

Revision as of 08:07, 28 July 2008

Image:2vp0.png

Template:STRUCTURE 2vp0

STRUCTURAL STUDIES OF NUCLEOSIDE ANALOG AND FEEDBACK INHIBITOR BINDING TO DROSOPHILA MELANOGASTER MULTISUBSTRATE DEOXYRIBONUCLEOSIDE KINASE

Template:ABSTRACT PUBMED 18384378

About this Structure

2VP0 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase., Mikkelsen NE, Munch-Petersen B, Eklund H, FEBS J. 2008 May;275(9):2151-60. Epub 2008 Apr 1. PMID:18384378

Page seeded by OCA on Mon Jul 28 11:06:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vp0"
Personal tools