2bqv

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[[Image:2bqv.gif|left|200px]]
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{{Seed}}
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[[Image:2bqv.png|left|200px]]
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{{STRUCTURE_2bqv| PDB=2bqv | SCENE= }}
{{STRUCTURE_2bqv| PDB=2bqv | SCENE= }}
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'''HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455'''
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===HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455===
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==Overview==
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Novel HIV-1 protease inhibitors encompassing a tertiary alcohol as part of the transition-state mimicking unit have been synthesized. Variation of the P1'-P3' residues and alteration of the tertiary alcohol absolute stereochemistry afforded 10 inhibitors. High potencies for the compounds with (S)-configuration at the carbon carrying the tertiary hydroxyl group were achieved with Ki values down to 2.4 nM. X-ray crystallographic data for a representative compound in complex with HIV-1 protease are presented.
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(as it appears on PubMed at http://www.pubmed.gov), where 16335934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16335934}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase complex]]
[[Category: Hydrolase complex]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:39:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:07:54 2008''

Revision as of 08:08, 28 July 2008

Image:2bqv.png

Template:STRUCTURE 2bqv

HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455

Template:ABSTRACT PUBMED 16335934

About this Structure

2BQV is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold., Ekegren JK, Unge T, Safa MZ, Wallberg H, Samuelsson B, Hallberg A, J Med Chem. 2005 Dec 15;48(25):8098-102. PMID:16335934

Page seeded by OCA on Mon Jul 28 11:07:54 2008

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