1yok

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[[Image:1yok.gif|left|200px]]
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{{Seed}}
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[[Image:1yok.png|left|200px]]
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{{STRUCTURE_1yok| PDB=1yok | SCENE= }}
{{STRUCTURE_1yok| PDB=1yok | SCENE= }}
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'''crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol'''
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===crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol===
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==Overview==
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Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors.
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The line below this paragraph, {{ABSTRACT_PUBMED_15707893}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15707893 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15707893}}
==About this Structure==
==About this Structure==
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[[Category: Phosphatidylglycerol]]
[[Category: Phosphatidylglycerol]]
[[Category: Tif-1]]
[[Category: Tif-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:35:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:15:38 2008''

Revision as of 08:15, 28 July 2008

Image:1yok.png

Template:STRUCTURE 1yok

crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol

Template:ABSTRACT PUBMED 15707893

About this Structure

1YOK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1., Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA, Cell. 2005 Feb 11;120(3):343-55. PMID:15707893

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