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2akf

From Proteopedia

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[[Image:2akf.gif|left|200px]]
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{{Seed}}
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[[Image:2akf.png|left|200px]]
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{{STRUCTURE_2akf| PDB=2akf | SCENE= }}
{{STRUCTURE_2akf| PDB=2akf | SCENE= }}
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'''Crystal structure of the coiled-coil domain of coronin 1'''
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===Crystal structure of the coiled-coil domain of coronin 1===
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==Overview==
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In recent years, short coiled coils have been used for applications ranging from biomaterial to medical sciences. For many of these applications knowledge of the factors that control the topology of the engineered protein systems is essential. Here, we demonstrate that trimerization of short coiled coils is determined by a distinct structural motif that encompasses specific networks of surface salt bridges and optimal hydrophobic packing interactions. The motif is conserved among intracellular, extracellular, viral, and synthetic proteins and defines a universal molecular determinant for trimer formation of short coiled coils. In addition to being of particular interest for the biotechnological production of candidate therapeutic proteins, these findings may be of interest for viral drug development strategies.
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The line below this paragraph, {{ABSTRACT_PUBMED_16172398}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16172398 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16172398}}
==About this Structure==
==About this Structure==
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[[Category: Coiled coil]]
[[Category: Coiled coil]]
[[Category: Coronin 1]]
[[Category: Coronin 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:09:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:16:14 2008''

Revision as of 08:16, 28 July 2008

Image:2akf.png

Template:STRUCTURE 2akf

Crystal structure of the coiled-coil domain of coronin 1

Template:ABSTRACT PUBMED 16172398

About this Structure

2AKF is a Single protein structure. Full crystallographic information is available from OCA.

Reference

A conserved trimerization motif controls the topology of short coiled coils., Kammerer RA, Kostrewa D, Progias P, Honnappa S, Avila D, Lustig A, Winkler FK, Pieters J, Steinmetz MO, Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13891-6. Epub 2005 Sep 19. PMID:16172398

Page seeded by OCA on Mon Jul 28 11:16:14 2008

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