2rko

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{{STRUCTURE_2rko| PDB=2rko | SCENE= }}
{{STRUCTURE_2rko| PDB=2rko | SCENE= }}
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'''Crystal Structure of the Vps4p-dimer'''
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===Crystal Structure of the Vps4p-dimer===
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==Overview==
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The vacuolar protein sorting (Vps) pathway, in which Vps4 class I AAA-ATPases play a central role, regulates growth factor receptors, immune response, and developmental signaling, and participates in tumor suppression, apoptosis, and retrovirus budding. We present the first atomic structure of the nucleotide-free yeast His(6)DeltaNVps4p dimer and its AMPPNP (5'-adenylyl-beta,gamma-imidodiphosphate)-bound tetradecamer, derived from a cryo electron microscopy map. Vps4p dimers form two distinct heptameric rings and accommodate AAA cassettes in a head-to-head-not in a head-to-tail-fashion as in class II AAA-ATPases. Our model suggests a mechanism for disassembling ESCRT (endosomal sorting complex required for transport) complexes by movements of substrate-binding domains located at the periphery of the tetradecamer during ATP hydrolysis in one ring, followed by translocation through the central pore and ATP hydrolysis in the second ring.
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(as it appears on PubMed at http://www.pubmed.gov), where 18272179 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18272179}}
==About this Structure==
==About this Structure==
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[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:05:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:18:52 2008''

Revision as of 08:19, 28 July 2008

Image:2rko.png

Template:STRUCTURE 2rko

Crystal Structure of the Vps4p-dimer

Template:ABSTRACT PUBMED 18272179

About this Structure

2RKO is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Vacuolar Protein Sorting: Two Different Functional States of the AAA-ATPase Vps4p., Hartmann C, Chami M, Zachariae U, de Groot BL, Engel A, Grutter MG, J Mol Biol. 2008 Jan 15;. PMID:18272179

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