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2pnd

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{{STRUCTURE_2pnd| PDB=2pnd | SCENE= }}
{{STRUCTURE_2pnd| PDB=2pnd | SCENE= }}
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'''Structure or murine CRIg'''
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===Structure or murine CRIg===
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==Overview==
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Complement is an important component of the innate and adaptive immune response, yet complement split products generated through activation of each of the three complement pathways (classical, alternative, and lectin) can cause inflammation and tissue destruction. Previous studies have shown that complement activation through the alternative, but not classical, pathway is required to initiate antibody-induced arthritis in mice, but it is unclear if the alternative pathway (AP) plays a role in established disease. Previously, we have shown that human complement receptor of the immunoglobulin superfamily (CRIg) is a selective inhibitor of the AP of complement. Here, we present the crystal structure of murine CRIg and, using mutants, provide evidence that the structural requirements for inhibition of the AP are conserved in human and mouse. A soluble form of CRIg reversed inflammation and bone loss in two experimental models of arthritis by inhibiting the AP of complement in the joint. Our data indicate that the AP of complement is not only required for disease induction, but also disease progression. The extracellular domain of CRIg thus provides a novel tool to study the effects of inhibiting the AP of complement in established disease and constitutes a promising therapeutic with selectivity for a single complement pathway.
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The line below this paragraph, {{ABSTRACT_PUBMED_17548523}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17548523 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17548523}}
==About this Structure==
==About this Structure==
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[[Category: Complement receptor]]
[[Category: Complement receptor]]
[[Category: Ig-like domain]]
[[Category: Ig-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:28:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:21:29 2008''

Revision as of 08:21, 28 July 2008

Image:2pnd.png

Template:STRUCTURE 2pnd

Structure or murine CRIg

Template:ABSTRACT PUBMED 17548523

About this Structure

2PND is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis., Katschke KJ Jr, Helmy KY, Steffek M, Xi H, Yin J, Lee WP, Gribling P, Barck KH, Carano RA, Taylor RE, Rangell L, Diehl L, Hass PE, Wiesmann C, van Lookeren Campagne M, J Exp Med. 2007 Jun 11;204(6):1319-25. Epub 2007 Jun 4. PMID:17548523

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