2c41

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{{STRUCTURE_2c41| PDB=2c41 | SCENE= }}
{{STRUCTURE_2c41| PDB=2c41 | SCENE= }}
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'''X-RAY STRUCTURE OF DPS FROM THERMOSYNECHOCOCCUS ELONGATUS'''
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===X-RAY STRUCTURE OF DPS FROM THERMOSYNECHOCOCCUS ELONGATUS===
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==Overview==
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DNA-binding proteins from starved cells (Dps proteins) protect bacteria primarily from oxidative damage. They are composed of 12 identical subunits assembled with 23-symmetry to form a compact cage-like structure known to be stable at temperatures &gt; 70 degrees C and over a wide pH range. Thermosynechococcus elongatus Dps thermostability is increased dramatically relative to mesophilic Dps proteins. Hydrophobic interactions at the dimeric and trimeric interfaces called Dps-like are replaced by salt bridges and hydrogen bonds, a common strategy in thermophiles. Moreover, the buried surface area at the least-extended Dps-like interface is significantly increased. A peculiarity of T. elongatus Dps is the presence of a chloride ion coordinated with threefold symmetry-related arginine residues lining the opening of the Dps-like pore toward the internal cavity. T. elongatus Dps conserves the unusual intersubunit ferroxidase centre that allows the Dps protein family to oxidize Fe(II) with hydrogen peroxide, thereby inhibiting free radical production via Fenton chemistry. This catalytic property is of special importance in T. elongatus (which lacks the catalase gene) in the protection of DNA and photosystems I and II from hydrogen peroxide-mediated oxidative damage.
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{{ABSTRACT_PUBMED_17018059}}
==About this Structure==
==About this Structure==
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[[Category: Thermophilic cyanobacterium]]
[[Category: Thermophilic cyanobacterium]]
[[Category: Thermostable protein]]
[[Category: Thermostable protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:13:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:23:26 2008''

Revision as of 08:23, 28 July 2008

Image:2c41.png

Template:STRUCTURE 2c41

X-RAY STRUCTURE OF DPS FROM THERMOSYNECHOCOCCUS ELONGATUS

Template:ABSTRACT PUBMED 17018059

About this Structure

2C41 is a Single protein structure of sequence from Thermosynechococcus elongatus. Full crystallographic information is available from OCA.

Reference

Antioxidant Dps protein from the thermophilic cyanobacterium Thermosynechococcus elongatus., Franceschini S, Ceci P, Alaleona F, Chiancone E, Ilari A, FEBS J. 2006 Nov;273(21):4913-28. Epub 2006 Oct 3. PMID:17018059

Page seeded by OCA on Mon Jul 28 11:23:26 2008

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