1n7d

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{{STRUCTURE_1n7d| PDB=1n7d | SCENE= }}
{{STRUCTURE_1n7d| PDB=1n7d | SCENE= }}
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'''Extracellular domain of the LDL receptor'''
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===Extracellular domain of the LDL receptor===
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==Overview==
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The low-density lipoprotein receptor mediates cholesterol homeostasis through endocytosis of lipoproteins. It discharges its ligand in the endosome at pH &lt; 6. In the crystal structure at pH = 5.3, the ligand-binding domain (modules R2 to R7) folds back as an arc over the epidermal growth factor precursor homology domain (the modules A, B, beta propeller, and C). The modules R4 and R5, which are critical for lipoprotein binding, associate with the beta propeller via their calcium-binding loop. We propose a mechanism for lipoprotein release in the endosome whereby the beta propeller functions as an alternate substrate for the ligand-binding domain, binding in a calcium-dependent way and promoting lipoprotein release.
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(as it appears on PubMed at http://www.pubmed.gov), where 12459547 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12459547}}
==Disease==
==Disease==
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[[Category: Ldl]]
[[Category: Ldl]]
[[Category: Ldl-receptor]]
[[Category: Ldl-receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:11:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:32:57 2008''

Revision as of 08:33, 28 July 2008

Image:1n7d.png

Template:STRUCTURE 1n7d

Contents

Extracellular domain of the LDL receptor

Template:ABSTRACT PUBMED 12459547

Disease

Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]

About this Structure

1N7D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the LDL receptor extracellular domain at endosomal pH., Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J, Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29. PMID:12459547

Page seeded by OCA on Mon Jul 28 11:32:57 2008

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OCA

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