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2b5b

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{{STRUCTURE_2b5b| PDB=2b5b | SCENE= }}
{{STRUCTURE_2b5b| PDB=2b5b | SCENE= }}
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'''A reptilian defensin with anti-bacterial and anti-viral activity'''
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===A reptilian defensin with anti-bacterial and anti-viral activity===
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==Overview==
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Egg white of marine turtle Caretta caretta contains a small cationic protein but lacks lysozyme. The protein was sequenced by a combination of sequential Edman degradation, carboxypeptidase digestion, nuclear magnetic resonance (NMR) and electrospray ionization tandem mass spectrometry. The protein contains 36 amino acid residues of which six are half-cysteines. The three-dimensional structure of the protein was deduced from two-dimensional NMR experiments and was observed to be similar to vertebrate beta-defensins. However, disulfide connectivity is C1-C6/C2-C5/C3-C4; different from that of the vertebrate beta-defensins. The protein showed strong antibacterial activity against Escherichia coli and Salmonella typhimurium. The protein also showed significant antiviral activity against an enveloped rhabdovirus, Chandipura virus, which is an emerging human pathogen. This virus is also closely related to the vesicular stomatitis virus, whose growth was also inhibited. This small cationic protein is part of the innate immunity of this organism and replaces lysozyme in the egg. It has the potential to be developed as an antibacterial and antiviral agent.
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(as it appears on PubMed at http://www.pubmed.gov), where 16700051 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16700051}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B5B OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B5B OCA].
==Reference==
==Reference==
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[[Category: Sinha, N K.]]
[[Category: Sinha, N K.]]
[[Category: Antibiotic]]
[[Category: Antibiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:52:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:35:06 2008''

Revision as of 08:35, 28 July 2008

Image:2b5b.png

Template:STRUCTURE 2b5b

A reptilian defensin with anti-bacterial and anti-viral activity

Template:ABSTRACT PUBMED 16700051

About this Structure

Full experimental information is available from OCA.

Reference

Small cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity., Chattopadhyay S, Sinha NK, Banerjee S, Roy D, Chattopadhyay D, Roy S, Proteins. 2006 Aug 1;64(2):524-31. PMID:16700051

Page seeded by OCA on Mon Jul 28 11:35:06 2008

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