2gas

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{{STRUCTURE_2gas| PDB=2gas | SCENE= }}
{{STRUCTURE_2gas| PDB=2gas | SCENE= }}
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'''Crystal Structure of Isoflavone Reductase'''
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===Crystal Structure of Isoflavone Reductase===
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==Overview==
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Isoflavonoids play important roles in plant defense and exhibit a range of mammalian health-promoting activities. Isoflavone reductase (IFR) specifically recognizes isoflavones and catalyzes a stereospecific NADPH-dependent reduction to (3R)-isoflavanone. The crystal structure of Medicago sativa IFR with deletion of residues 39-47 has been determined at 1.6A resolution. Structural analysis, molecular modeling and docking, and comparison with the structures of other NADPH-dependent enzymes, defined the putative binding sites for co-factor and substrate and potential key residues for enzyme activity and substrate specificity. Further mutagenesis has confirmed the role of Lys144 as a catalytic residue. This study provides a structural basis for understanding the enzymatic mechanism and substrate specificity of IFRs as well as the functions of IFR-like proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 16600295 is the PubMed ID number.
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==About this Structure==
==About this Structure==
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[[Category: Wang, X.]]
[[Category: Wang, X.]]
[[Category: Nadph-dependent reductase]]
[[Category: Nadph-dependent reductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:37:09 2008''

Revision as of 08:37, 28 July 2008

Image:2gas.png

Template:STRUCTURE 2gas

Crystal Structure of Isoflavone Reductase

Template:ABSTRACT PUBMED 16600295

About this Structure

2GAS is a Single protein structure of sequence from Medicago sativa. Full crystallographic information is available from OCA.

Reference

Crystal structure of isoflavone reductase from alfalfa (Medicago sativa L.)., Wang X, He X, Lin J, Shao H, Chang Z, Dixon RA, J Mol Biol. 2006 May 19;358(5):1341-52. Epub 2006 Mar 29. PMID:16600295

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