1oxz

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{{STRUCTURE_1oxz| PDB=1oxz | SCENE= }}
{{STRUCTURE_1oxz| PDB=1oxz | SCENE= }}
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'''Crystal Structure of the Human GGA1 GAT domain'''
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===Crystal Structure of the Human GGA1 GAT domain===
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==Overview==
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GGAs are a family of vesicle-coating regulatory proteins that function in intracellular protein transport. A GGA molecule contains four domains, each mediating interaction with other proteins in carrying out intracellular transport. The GAT domain of GGAs has been identified as the structural entity that binds membrane-bound ARF, a molecular switch regulating vesicle-coat assembly. It also directly interacts with rabaptin5, an essential component of endosome fusion. A 2.8 A resolution crystal structure of the human GGA1 GAT domain is reported here. The GAT domain contains four helices and has an elongated shape with the longest dimension exceeding 80 A. Its longest helix is involved in two structural motifs: an N-terminal helix-loop-helix motif and a C-terminal three-helix bundle. The N-terminal motif harbors the most conservative amino acid sequence in the GGA GAT domains. Within this conserved region, a cluster of residues previously implicated in ARF binding forms a hydrophobic surface patch, which is likely to be the ARF-binding site. In addition, a structure-based mutagenesis-biochemical analysis demonstrates that the C-terminal three-helix bundle of this GAT domain is responsible for the rabaptin5 binding. These structural characteristics are consistent with a model supporting multiple functional roles for the GAT domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 12767220 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12767220}}
==About this Structure==
==About this Structure==
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[[Category: Gat domain]]
[[Category: Gat domain]]
[[Category: Gga1]]
[[Category: Gga1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:25:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:39:25 2008''

Revision as of 08:39, 28 July 2008

Image:1oxz.png

Template:STRUCTURE 1oxz

Crystal Structure of the Human GGA1 GAT domain

Template:ABSTRACT PUBMED 12767220

About this Structure

1OXZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human GGA1 GAT domain., Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC, Biochemistry. 2003 Jun 3;42(21):6392-9. PMID:12767220

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