1u09

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{{STRUCTURE_1u09| PDB=1u09 | SCENE= }}
{{STRUCTURE_1u09| PDB=1u09 | SCENE= }}
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'''Footand Mouth Disease Virus RNA-dependent RNA polymerase'''
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===Footand Mouth Disease Virus RNA-dependent RNA polymerase===
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==Overview==
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Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. The enzyme performs this operation, together with other viral and probably host proteins, in the cytoplasm of their host cells. The crystal structure of the 3D polymerase of foot-and-mouth disease virus, one of the most important animal pathogens, has been determined unliganded and bound to a template-primer RNA decanucleotide. The enzyme folds in the characteristic fingers, palm and thumb subdomains, with the presence of an NH2-terminal segment that encircles the active site. In the complex, several conserved amino acid side chains bind to the template-primer, likely mediating the initiation of RNA synthesis. The structure provides essential information for studies on RNA replication and the design of antiviral compounds.
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(as it appears on PubMed at http://www.pubmed.gov), where 15294895 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15294895}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Rna-dependent rna polymerase]]
[[Category: Rna-dependent rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:35:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:40:48 2008''

Revision as of 08:40, 28 July 2008

Image:1u09.png

Template:STRUCTURE 1u09

Footand Mouth Disease Virus RNA-dependent RNA polymerase

Template:ABSTRACT PUBMED 15294895

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA., Ferrer-Orta C, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N, J Biol Chem. 2004 Nov 5;279(45):47212-21. Epub 2004 Aug 3. PMID:15294895

Page seeded by OCA on Mon Jul 28 11:40:48 2008

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