2siv

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{{STRUCTURE_2siv| PDB=2siv | SCENE= }}
{{STRUCTURE_2siv| PDB=2siv | SCENE= }}
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'''SIV GP41 CORE STRUCTURE'''
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===SIV GP41 CORE STRUCTURE===
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==Overview==
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The gp41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) mediates membrane fusion during viral entry. The crystal structure of the HIV-1 gp41 ectodomain core in its proposed fusion-active state is a six-helix bundle. Here we have reconstituted the core of the SIV gp41 ectodomain with two synthetic peptides called SIV N36 and SIV C34, which form a highly helical trimer of heterodimers. The 2.2 A resolution crystal structure of this SIV N36/C34 complex is very similar to the analogous structure in HIV-1 gp41. In both structures, three N36 helices form a central trimeric coiled coil. Three C34 helices pack in an antiparallel orientation into highly conserved, hydrophobic grooves along the surface of this coiled coil. The conserved nature of the N36-C34 interface suggests that the HIV-1 and SIV peptides are functionally interchangeable. Indeed, a heterotypic complex between HIV-1 N36 and SIV C34 peptides is highly helical and stable. Moreover, as with HIV-1 C34, the SIV C34 peptide is a potent inhibitor of HIV-1 infection. These results identify conserved packing interactions between the N and C helices of gp41 and have implications for the development of C peptide analogs with broad inhibitory activity.
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{{ABSTRACT_PUBMED_9689046}}
==About this Structure==
==About this Structure==
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[[Category: Retrovirus]]
[[Category: Retrovirus]]
[[Category: Siv]]
[[Category: Siv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:19:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:41:27 2008''

Revision as of 08:41, 28 July 2008

Image:2siv.png

Template:STRUCTURE 2siv

SIV GP41 CORE STRUCTURE

Template:ABSTRACT PUBMED 9689046

About this Structure

2SIV is a Protein complex structure of sequences from Simian immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides., Malashkevich VN, Chan DC, Chutkowski CT, Kim PS, Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9134-9. PMID:9689046

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