2g0k

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{{STRUCTURE_2g0k| PDB=2g0k | SCENE= }}
{{STRUCTURE_2g0k| PDB=2g0k | SCENE= }}
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'''Solution Structure of Neocarzinostatin Apo-Protein'''
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===Solution Structure of Neocarzinostatin Apo-Protein===
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==Overview==
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Neocarzinostatin (NCS) is a 1:1 complex of an enediyne chromophore (NCSChrom), non-covalently bound to an 11 kDa protein (apoNCS). We are exploring apoNCS as a generic protein system for sequestering small molecules for therapeutic applications. Here, we disclose a new flavone ligand 1 for apoNCS and present a high-resolution NMR structure of this ligand bound to apoNCS. This is the first high-resolution structure of a completely non-cognate ligand bound to the apoNCS protein. This work provides unambiguous evidence that a completely new class of ligand can bind specifically to apoNCS. Furthermore, the mode of binding is different than that of the naphthoate-based ligands, and for such a simple hydrophobic compound, the new ligand surprisingly binds specifically. This work indicates that apo-Neocarzinostatin has multiple selective and distinct binding modes for small-molecule cargo.
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The line below this paragraph, {{ABSTRACT_PUBMED_16568976}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16568976 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16568976}}
==About this Structure==
==About this Structure==
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2G0K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0K OCA].
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2G0K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0K OCA].
==Reference==
==Reference==
Synthetic ligands for apo-neocarzinostatin., Caddick S, Muskett FW, Stoneman RG, Woolfson DN, J Am Chem Soc. 2006 Apr 5;128(13):4204-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16568976 16568976]
Synthetic ligands for apo-neocarzinostatin., Caddick S, Muskett FW, Stoneman RG, Woolfson DN, J Am Chem Soc. 2006 Apr 5;128(13):4204-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16568976 16568976]
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Solution structure of a novel chromoprotein derived from apo-neocarzinostatin and a synthetic chromophore., Urbaniak MD, Muskett FW, Finucane MD, Caddick S, Woolfson DN, Biochemistry. 2002 Oct 1;41(39):11731-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12269815 12269815]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptomyces carzinostaticus]]
[[Category: Streptomyces carzinostaticus]]
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Igg fold]]
[[Category: Igg fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:33:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:41:56 2008''

Revision as of 08:42, 28 July 2008

Image:2g0k.png

Template:STRUCTURE 2g0k

Solution Structure of Neocarzinostatin Apo-Protein

Template:ABSTRACT PUBMED 16568976

About this Structure

2G0K is a Single protein structure of sequence from Streptomyces carzinostaticus. Full experimental information is available from OCA.

Reference

Synthetic ligands for apo-neocarzinostatin., Caddick S, Muskett FW, Stoneman RG, Woolfson DN, J Am Chem Soc. 2006 Apr 5;128(13):4204-5. PMID:16568976

Solution structure of a novel chromoprotein derived from apo-neocarzinostatin and a synthetic chromophore., Urbaniak MD, Muskett FW, Finucane MD, Caddick S, Woolfson DN, Biochemistry. 2002 Oct 1;41(39):11731-9. PMID:12269815

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