1nix

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[[Image:1nix.jpg|left|200px]]
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{{STRUCTURE_1nix| PDB=1nix | SCENE= }}
{{STRUCTURE_1nix| PDB=1nix | SCENE= }}
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'''THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR'''
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===THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR===
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==Overview==
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Hainantoxin-I is a novel peptide toxin, purified from the venom of the Chinese bird spider Selenocosmia hainana (=Ornithoctonus hainana). It includes 33 amino acid residues with a disulfide linkage of I-IV, II-V and III-VI, assigned by partial reduction and sequence analysis. Under two-electrode voltage-clamp conditions, hainantoxin-I can block rNa(v)1.2/beta(1) and the insect sodium channel para/tipE expressed in Xenopus laevis oocytes with IC(50) values of 68+/-6 microM and 4.3+/-0.3 microM respectively. The three-dimensional solution structure of hainantoxin-I belongs to the inhibitor cystine knot structural family determined by two-dimensional (1)H nuclear magnetic resonance techniques. Structural comparison of hainantoxin-I with those of other toxins suggests that the combination of the charged residues and a vicinal hydrophobic patch should be responsible for ligand binding. This is the first report of an insect sodium channel blocker from spider venom and it provides useful information for the structure-function relationship studies of insect sodium channels.
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(as it appears on PubMed at http://www.pubmed.gov), where 14675784 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14675784}}
==About this Structure==
==About this Structure==
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1NIX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_hainana Ornithoctonus hainana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NIX OCA].
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1NIX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_hainana Ornithoctonus hainana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NIX OCA].
==Reference==
==Reference==
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[[Category: Liang, S.]]
[[Category: Liang, S.]]
[[Category: Inhibitor cystine knot motif]]
[[Category: Inhibitor cystine knot motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:35:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:42:08 2008''

Revision as of 08:42, 28 July 2008

Image:1nix.png

Template:STRUCTURE 1nix

THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR

Template:ABSTRACT PUBMED 14675784

About this Structure

1NIX is a Single protein structure of sequence from Ornithoctonus hainana. Full experimental information is available from OCA.

Reference

Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana., Li D, Xiao Y, Hu W, Xie J, Bosmans F, Tytgat J, Liang S, FEBS Lett. 2003 Dec 18;555(3):616-22. PMID:14675784

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