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2pee

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{{STRUCTURE_2pee| PDB=2pee | SCENE= }}
{{STRUCTURE_2pee| PDB=2pee | SCENE= }}
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'''Crystal Structure of a Thermophilic Serpin, Tengpin, in the Native State'''
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===Crystal Structure of a Thermophilic Serpin, Tengpin, in the Native State===
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==Overview==
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Serpins fold to a metastable native state and are susceptible to undergoing spontaneous conformational change to more stable conformers, such as the latent form. We investigated conformational change in tengpin, an unusual prokaryotic serpin from the extremophile Thermoanaerobacter tengcongensis. In addition to the serpin domain, tengpin contains a functionally uncharacterized 56-amino-acid amino-terminal region. Deletion of this domain creates a variant--tengpinDelta51--which folds past the native state and readily adopts the latent conformation. Analysis of crystal structures together with mutagenesis studies show that the N terminus of tengpin protects a hydrophobic patch in the serpin domain and functions to trap tengpin in its native metastable state. A 13-amino-acid peptide derived from the N terminus is able to mimick the role of the N terminus in stabilizing the native state of tengpinDelta51. Therefore, the function of the N terminus in tengpin resembles protein cofactors that prevent mammalian serpins from spontaneously adopting the latent conformation.
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{{ABSTRACT_PUBMED_17557112}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, Q W.]]
[[Category: Zhang, Q W.]]
[[Category: Thermophilic serpin]]
[[Category: Thermophilic serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:57:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:45:27 2008''

Revision as of 08:45, 28 July 2008

Image:2pee.png

Template:STRUCTURE 2pee

Crystal Structure of a Thermophilic Serpin, Tengpin, in the Native State

Template:ABSTRACT PUBMED 17557112

About this Structure

2PEE is a Single protein structure of sequence from Thermoanaerobacter tengcongensis. Full crystallographic information is available from OCA.

Reference

The N terminus of the serpin, tengpin, functions to trap the metastable native state., Zhang Q, Buckle AM, Law RH, Pearce MC, Cabrita LD, Lloyd GJ, Irving JA, Smith AI, Ruzyla K, Rossjohn J, Bottomley SP, Whisstock JC, EMBO Rep. 2007 Jul;8(7):658-63. Epub 2007 Jun 8. PMID:17557112

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