2e2h

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[[Image:2e2h.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2e2h| PDB=2e2h | SCENE= }}
{{STRUCTURE_2e2h| PDB=2e2h | SCENE= }}
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'''RNA polymerase II elongation complex at 5 mM Mg2+ with GTP'''
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===RNA polymerase II elongation complex at 5 mM Mg2+ with GTP===
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==Overview==
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New structures of RNA polymerase II (pol II) transcribing complexes reveal a likely key to transcription. The trigger loop swings beneath a correct nucleoside triphosphate (NTP) in the nucleotide addition site, closing off the active center and forming an extensive network of interactions with the NTP base, sugar, phosphates, and additional pol II residues. A histidine side chain in the trigger loop, precisely positioned by these interactions, may literally "trigger" phosphodiester bond formation. Recognition and catalysis are thus coupled, ensuring the fidelity of transcription.
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(as it appears on PubMed at http://www.pubmed.gov), where 17129781 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17129781}}
==About this Structure==
==About this Structure==
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[[Category: Multiprotein complex]]
[[Category: Multiprotein complex]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:47:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:49:57 2008''

Revision as of 08:50, 28 July 2008

Image:2e2h.png

Template:STRUCTURE 2e2h

RNA polymerase II elongation complex at 5 mM Mg2+ with GTP

Template:ABSTRACT PUBMED 17129781

About this Structure

2E2H is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis., Wang D, Bushnell DA, Westover KD, Kaplan CD, Kornberg RD, Cell. 2006 Dec 1;127(5):941-54. PMID:17129781

Page seeded by OCA on Mon Jul 28 11:49:57 2008

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