1oqs

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{{STRUCTURE_1oqs| PDB=1oqs | SCENE= }}
{{STRUCTURE_1oqs| PDB=1oqs | SCENE= }}
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'''Crystal Structure of RV4/RV7 Complex'''
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===Crystal Structure of RV4/RV7 Complex===
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==Overview==
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The presynaptic viperotoxin F is the major lethal component of the venom of Vipera russelli formosensis (Taiwan viper). It is a heterodimer of two highly homologous (65% identity) but oppositely charged subunits: a basic and neurotoxic PLA(2) (RV-4) and an acidic non-toxic component with a very low enzymatic activity (RV-7). The crystal structure of the complex has been determined by molecular replacement and refined to 1.9 A resolution and an R factor of 22.3% with four RV-4/RV-7 complexes in the asymmetric unit, which do not exhibit any local point-group symmetry. The complex formation decreases the accessible surface area of the two subunits by approximately 1425 A(2). Both PLA(2)s are predicted to have very low, if any, anticoagulant activity. The structure of viperotoxin F is compared with that of the heterodimeric neurotoxin vipoxin from the venom of another viper, V. ammodytes meridionalis. The structural basis for the differences between the pharmacological activities of the two toxins is discussed. The neutralization of the negative charge of the major ligand for Ca(2+), Asp49, by intersubunit salt bridges is probably a common mechanism of self-stabilization of heterodimeric Viperinae snake-venom neurotoxins in the absence of bound calcium.
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{{ABSTRACT_PUBMED_14501106}}
==About this Structure==
==About this Structure==
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[[Category: Perbandt, M.]]
[[Category: Perbandt, M.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:54:11 2008''

Revision as of 08:54, 28 July 2008

Image:1oqs.png

Template:STRUCTURE 1oqs

Crystal Structure of RV4/RV7 Complex

Template:ABSTRACT PUBMED 14501106

About this Structure

1OQS is a Protein complex structure of sequences from Daboia russellii siamensis. Full crystallographic information is available from OCA.

Reference

Structure of the heterodimeric neurotoxic complex viperotoxin F (RV-4/RV-7) from the venom of Vipera russelli formosensis at 1.9 A resolution., Perbandt M, Tsai IH, Fuchs A, Banumathi S, Rajashankar KR, Georgieva D, Kalkura N, Singh TP, Genov N, Betzel C, Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1679-87. Epub 2003, Sep 19. PMID:14501106

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