1yny

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[[Image:1yny.gif|left|200px]]
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{{STRUCTURE_1yny| PDB=1yny | SCENE= }}
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'''Molecular Structure of D-Hydantoinase from a Bacillus sp. AR9: Evidence for mercury inhibition'''
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===Molecular Structure of D-Hydantoinase from a Bacillus sp. AR9: Evidence for mercury inhibition===
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==Overview==
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Stereospecific conversion of hydantoins into their carbamoyl acid derivatives could be achieved by using the enzyme hydantoinase. Specific hydantoinases convert either the D-form or the L-form of the hydantoin and the amino acids responsible for stereospecificity have not been identified. Structural studies on hydantoinases from a few bacterial species were published recently. The structure of a thermostable D-hydantoinase from Bacillus sp. AR9 (bar9HYD) was solved to 2.3 angstroms resolution. The usual modification of carboxylation of the active-site residue Lys150 did not happen in bar9HYD. Two manganese ions were modelled in the active site. Through biochemical studies, it was shown that mercury inhibits the activity of the enzyme. The mercury derivative provided some information about the binding site of the mercuric inhibitors and a possible reason for inhibition is presented.
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(as it appears on PubMed at http://www.pubmed.gov), where 15733920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15733920}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Tim-barrel]]
[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:33:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:55:53 2008''

Revision as of 08:55, 28 July 2008

Image:1yny.png

Template:STRUCTURE 1yny

Molecular Structure of D-Hydantoinase from a Bacillus sp. AR9: Evidence for mercury inhibition

Template:ABSTRACT PUBMED 15733920

About this Structure

Full crystallographic information is available from OCA.

Reference

Molecular structure of D-hydantoinase from Bacillus sp. AR9: evidence for mercury inhibition., Radha Kishan KV, Vohra RM, Ganesan K, Agrawal V, Sharma VM, Sharma R, J Mol Biol. 2005 Mar 18;347(1):95-105. Epub 2005 Jan 27. PMID:15733920

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