1qzu

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[[Image:1qzu.jpg|left|200px]]
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{{STRUCTURE_1qzu| PDB=1qzu | SCENE= }}
{{STRUCTURE_1qzu| PDB=1qzu | SCENE= }}
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'''crystal structure of human phosphopantothenoylcysteine decarboxylase'''
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===crystal structure of human phosphopantothenoylcysteine decarboxylase===
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==Overview==
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Phosphopantothenoylcysteine (PPC) decarboxylase is an essential enzyme in the biosynthesis of coenzyme A and catalyzes the decarboxylation of PPC to phosphopantetheine. Human PPC decarboxylase has been expressed in Escherichia coli, purified and crystallized. The Laue class of the diffraction data appears to be 3m, suggesting space group R32 with two monomers per asymmetric unit. However, the crystals belong to the space group R3 and the asymmetric unit contains four monomers. The structure has been solved using molecular replacement and refined to a current R factor of 29%. The crystal packing can be considered as two interlaced lattices, each consistent with space group R32 and with the corresponding twofold axes parallel to each other but separated along the threefold axis. Thus, the true space group is R3 with four monomers per asymmetric unit.
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The line below this paragraph, {{ABSTRACT_PUBMED_14501115}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14501115 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14501115}}
==About this Structure==
==About this Structure==
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[[Category: Manoj, N.]]
[[Category: Manoj, N.]]
[[Category: Alpha-beta sandwich]]
[[Category: Alpha-beta sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:54:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:55:48 2008''

Revision as of 08:55, 28 July 2008

Image:1qzu.png

Template:STRUCTURE 1qzu

crystal structure of human phosphopantothenoylcysteine decarboxylase

Template:ABSTRACT PUBMED 14501115

About this Structure

1QZU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase., Manoj N, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1762-6. Epub 2003, Sep 19. PMID:14501115

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