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1or8

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{{STRUCTURE_1or8| PDB=1or8 | SCENE= }}
{{STRUCTURE_1or8| PDB=1or8 | SCENE= }}
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'''Structure of the Predominant protein arginine methyltransferase PRMT1'''
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===Structure of the Predominant protein arginine methyltransferase PRMT1===
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==Overview==
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PRMT1 is the predominant type I protein arginine methyltransferase in mammals and highly conserved among all eukaryotes. It is essential for early postimplantation development in mouse. Here we describe the crystal structure of rat PRMT1 in complex with the reaction product AdoHcy and a 19 residue substrate peptide containing three arginines. The results reveal a two-domain structure-an AdoMet binding domain and a barrel-like domain-with the active site pocket located between the two domains. Mutagenesis studies confirmed that two active site glutamates are essential for enzymatic activity, and that dimerization of PRMT1 is essential for AdoMet binding. Three peptide binding channels are identified: two are between the two domains, and the third is on the surface perpendicular to the strands forming the beta barrel.
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{{ABSTRACT_PUBMED_12737817}}
==About this Structure==
==About this Structure==
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[[Category: Adomet-dependent methylation]]
[[Category: Adomet-dependent methylation]]
[[Category: Protein arginine methylation]]
[[Category: Protein arginine methylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:11:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:58:08 2008''

Revision as of 08:58, 28 July 2008

Image:1or8.png

Template:STRUCTURE 1or8

Structure of the Predominant protein arginine methyltransferase PRMT1

Template:ABSTRACT PUBMED 12737817

About this Structure

1OR8 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides., Zhang X, Cheng X, Structure. 2003 May;11(5):509-20. PMID:12737817

Page seeded by OCA on Mon Jul 28 11:58:08 2008

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