2csa

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[[Image:2csa.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2csa| PDB=2csa | SCENE= }}
{{STRUCTURE_2csa| PDB=2csa | SCENE= }}
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'''Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal'''
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===Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal===
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==Overview==
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Muscarinic acetylcholine receptors comprise a family of G-protein-coupled receptors that display differential localization in polarized epithelial cells. We identify a seven-residue sequence, Ala(275)-Val(281), in the third intracellular loop of the M(3) muscarinic receptor that mediates dominant, position-independent basolateral targeting in Madin-Darby canine kidney cells. Mutational analyses identify Glu(276), Phe(280), and Val(281) as critical residues within this sorting motif. Phe(280) and Val(281) comprise a novel dihydrophobic sorting signal as mutations of either residue singly or together with leucine do not disrupt basolateral targeting. Conversely, Glu(276) is required and cannot be substituted with alanine or aspartic acid. A 19-amino acid peptide representing the M(3) sorting signal and surrounding sequence was analyzed via two-dimensional nuclear magnetic resonance spectroscopy. Solution structures show that Glu(276) resides in a type IV beta-turn and the dihydrophobic sequence Phe(280)Val(281) adopts either a type I or IV beta-turn.
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The line below this paragraph, {{ABSTRACT_PUBMED_15870063}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15870063 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15870063}}
==About this Structure==
==About this Structure==
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2CSA is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].
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2CSA is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].
==Reference==
==Reference==
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[[Category: Nathanson, N M.]]
[[Category: Nathanson, N M.]]
[[Category: Basolateral sorting-signal blss beta-turn]]
[[Category: Basolateral sorting-signal blss beta-turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:56:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:00:03 2008''

Revision as of 09:00, 28 July 2008

Image:2csa.png

Template:STRUCTURE 2csa

Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal

Template:ABSTRACT PUBMED 15870063

About this Structure

2CSA is a Single protein structure. Full experimental information is available from OCA.

Reference

Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal., Iverson HA, Fox D 3rd, Nadler LS, Klevit RE, Nathanson NM, J Biol Chem. 2005 Jul 1;280(26):24568-75. Epub 2005 May 2. PMID:15870063

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