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2pqz

From Proteopedia

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{{STRUCTURE_2pqz| PDB=2pqz | SCENE= }}
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'''HIV-1 Protease in complex with a pyrrolidine-based inhibitor'''
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===HIV-1 Protease in complex with a pyrrolidine-based inhibitor===
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==Overview==
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Infections with the human immunodeficiency virus, which inevitably lead to the development of AIDS, are still among the most serious global health problems causing more than 2.5 million deaths per year. In the pathophysiological processes of this pandemic, HIV protease has proven to be an invaluable drug target because of its essential role in the virus' replication process. By use of pyrrolidine as core structure, symmetric 3,4-bis- N-alkylsulfonamides were designed and synthesized enantioselectively from d-(-)-tartaric acid as a new class of HIV protease inhibitors. Structure-guided design using the cocrystal structure of an initial lead as starting point resulted in a second series of inhibitors with improved affinity. The binding modes of four representatives were determined by X-ray crystallography to elucidate the underlying factors accounting for the SAR. With this information for further rational design, the combination of suitable side chains resulted in a final inhibitor showing a significantly improved affinity of K i = 74 nM.
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(as it appears on PubMed at http://www.pubmed.gov), where 18348517 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18348517}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protein-ligand complex]]
[[Category: Protein-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 16 23:04:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:04:49 2008''

Revision as of 09:04, 28 July 2008

Image:2pqz.png

Template:STRUCTURE 2pqz

HIV-1 Protease in complex with a pyrrolidine-based inhibitor

Template:ABSTRACT PUBMED 18348517

About this Structure

2PQZ is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structure-Guided Design of C2-Symmetric HIV-1 Protease Inhibitors Based on a Pyrrolidine Scaffold., Blum A, Bottcher J, Heine A, Klebe G, Diederich WE, J Med Chem. 2008 Apr 10;51(7):2078-87. Epub 2008 Mar 19. PMID:18348517

Page seeded by OCA on Mon Jul 28 12:04:49 2008

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