1y6i

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{{STRUCTURE_1y6i| PDB=1y6i | SCENE= }}
{{STRUCTURE_1y6i| PDB=1y6i | SCENE= }}
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'''Synechocystis GUN4'''
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===Synechocystis GUN4===
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==Overview==
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In plants, the accumulation of the chlorophyll precursor Mg-protoporphyrin IX (Mg-Proto) in the plastid regulates the expression of a number of nuclear genes with functions related to photosynthesis. Analysis of the plastid-to-nucleus signaling activity of Mg-Proto in Arabidopsis thaliana led to the discovery of GUN4, a novel porphyrin-binding protein that also dramatically enhances the activity of Mg-chelatase, the enzyme that synthesizes Mg-Proto. GUN4 may also play a role in both photoprotection and the cellular shuttling of tetrapyrroles. Here we report a 1.78-A resolution crystal structure of Synechocystis GUN4, in which the porphyrin-binding domain adopts a unique three dimensional fold with a "cupped hand" shape. Biophysical and biochemical analyses revealed the specific site of interaction between GUN4 and Mg-Proto and the energetic determinants for the GUN4.Mg-Proto interaction. Our data support a novel protective function for GUN4 in tetrapyrrole trafficking. The combined structural and energetic analyses presented herein form the physical-chemical basis for understanding GUN4 biological activity, including its role in the stimulation of Mg-chelatase activity, as well as in Mg-Proto retrograde signaling.
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{{ABSTRACT_PUBMED_15884974}}
==About this Structure==
==About this Structure==
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[[Category: Helix-bundle]]
[[Category: Helix-bundle]]
[[Category: Porphyrin binding]]
[[Category: Porphyrin binding]]
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Revision as of 09:05, 28 July 2008

Image:1y6i.png

Template:STRUCTURE 1y6i

Synechocystis GUN4

Template:ABSTRACT PUBMED 15884974

About this Structure

1Y6I is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding., Verdecia MA, Larkin RM, Ferrer JL, Riek R, Chory J, Noel JP, PLoS Biol. 2005 May;3(5):e151. Epub 2005 Apr 26. PMID:15884974

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