1zun

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{{STRUCTURE_1zun| PDB=1zun | SCENE= }}
{{STRUCTURE_1zun| PDB=1zun | SCENE= }}
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'''Crystal Structure of a GTP-Regulated ATP Sulfurylase Heterodimer from Pseudomonas syringae'''
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===Crystal Structure of a GTP-Regulated ATP Sulfurylase Heterodimer from Pseudomonas syringae===
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==Overview==
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Sulfate assimilation is a critical component of both primary and secondary metabolism. An essential step in this pathway is the activation of sulfate through adenylation by the enzyme ATP sulfurylase (ATPS), forming adenosine 5'-phosphosulfate (APS). Proteobacterial ATPS overcomes this energetically unfavorable reaction by associating with a regulatory G protein, coupling the energy of GTP hydrolysis to APS formation. To discover the molecular basis of this unusual role for a G protein, we biochemically characterized and solved the X-ray crystal structure of a complex between Pseudomonas syringae ATPS (CysD) and its associated regulatory G protein (CysN). The structure of CysN*D shows the two proteins in tight association; however, the nucleotides bound to each subunit are spatially segregated. We provide evidence that conserved switch motifs in the G domain of CysN allosterically mediate interactions between the nucleotide binding sites. This structure suggests a molecular mechanism by which conserved G domain architecture is used to energetically link GTP turnover to the production of an essential metabolite.
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(as it appears on PubMed at http://www.pubmed.gov), where 16387658 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16387658}}
==About this Structure==
==About this Structure==
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[[Category: Pyrophosphate]]
[[Category: Pyrophosphate]]
[[Category: Switch domain]]
[[Category: Switch domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:05:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:05:50 2008''

Revision as of 09:06, 28 July 2008

Image:1zun.png

Template:STRUCTURE 1zun

Crystal Structure of a GTP-Regulated ATP Sulfurylase Heterodimer from Pseudomonas syringae

Template:ABSTRACT PUBMED 16387658

About this Structure

1ZUN is a Protein complex structure of sequences from Pseudomonas syringae and Pseudomonas syringae pv. tomato str. dc3000. Full crystallographic information is available from OCA.

Reference

Molecular basis for G protein control of the prokaryotic ATP sulfurylase., Mougous JD, Lee DH, Hubbard SC, Schelle MW, Vocadlo DJ, Berger JM, Bertozzi CR, Mol Cell. 2006 Jan 6;21(1):109-22. PMID:16387658

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