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2gkw

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[[Image:2gkw.gif|left|200px]]
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{{STRUCTURE_2gkw| PDB=2gkw | SCENE= }}
{{STRUCTURE_2gkw| PDB=2gkw | SCENE= }}
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'''Key contacts promote recongnito of BAFF-R by TRAF3'''
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===Key contacts promote recongnito of BAFF-R by TRAF3===
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==Overview==
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B cell-activating factor belonging to the TNF family receptor (BAFF-R), a member of the TNFR superfamily, plays a role in autoimmunity after ligation with BAFF ligand (also called TALL-1, BLyS, THANK, or zTNF4). BAFF/BAFF-R interactions are critical for B cell regulation, and signaling from this ligand-receptor complex results in NF-kappaB activation. Most TNFRs transmit signals intracellularly by recruitment of adaptor proteins called TNFR-associated factors (TRAFs). However, BAFF-R binds only one TRAF adaptor, TRAF3, and this interaction negatively regulates activation of NF-kappaB. In this study, we report the crystal structure of a 24-residue fragment of the cytoplasmic portion of BAFF-R bound in complex with TRAF3. The recognition motif (162)PVPAT(166) in BAFF-R is accommodated in the same binding crevice on TRAF3 that binds two related TNFRs, CD40 and LTbetaR, but is presented in a completely different structural framework. This region of BAFF-R assumes an open conformation with two extended strands opposed at right angles that each make contacts with TRAF3. The recognition motif is located in the N-terminal arm and intermolecular contacts mediate TRAF recognition. In the C-terminal arm, key stabilizing contacts are made, including critical hydrogen bonds with Gln(379) in TRAF3 that define the molecular basis for selective binding of BAFF-R solely to this member of the TRAF family. A dynamic conformational adjustment of Tyr(377) in TRAF3 occurs forming a new intermolecular contact with BAFF-R that stabilizes the complex. The structure of the complex provides a molecular explanation for binding affinities and selective protein interactions in TNFR-TRAF interactions.
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The line below this paragraph, {{ABSTRACT_PUBMED_15585864}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15585864 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15585864}}
==About this Structure==
==About this Structure==
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[[Category: Nf-kb signaling]]
[[Category: Nf-kb signaling]]
[[Category: Traf3]]
[[Category: Traf3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:13:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:07:15 2008''

Revision as of 09:07, 28 July 2008

Image:2gkw.png

Template:STRUCTURE 2gkw

Key contacts promote recongnito of BAFF-R by TRAF3

Template:ABSTRACT PUBMED 15585864

About this Structure

2GKW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation., Ni CZ, Oganesyan G, Welsh K, Zhu X, Reed JC, Satterthwait AC, Cheng G, Ely KR, J Immunol. 2004 Dec 15;173(12):7394-400. PMID:15585864

Page seeded by OCA on Mon Jul 28 12:07:15 2008

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