2g0d

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[[Image:2g0d.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2g0d| PDB=2g0d | SCENE= }}
{{STRUCTURE_2g0d| PDB=2g0d | SCENE= }}
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'''Nisin cyclase'''
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===Nisin cyclase===
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==Overview==
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Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.
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(as it appears on PubMed at http://www.pubmed.gov), where 16527981 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16527981}}
==About this Structure==
==About this Structure==
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[[Category: Alpha barrel]]
[[Category: Alpha barrel]]
[[Category: Alpha toroid]]
[[Category: Alpha toroid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:33:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:10:27 2008''

Revision as of 09:10, 28 July 2008

Image:2g0d.png

Template:STRUCTURE 2g0d

Nisin cyclase

Template:ABSTRACT PUBMED 16527981

About this Structure

2G0D is a Single protein structure of sequence from Lactococcus lactis subsp. lactis. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:16527981

Page seeded by OCA on Mon Jul 28 12:10:27 2008

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