1pjh

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{{STRUCTURE_1pjh| PDB=1pjh | SCENE= }}
{{STRUCTURE_1pjh| PDB=1pjh | SCENE= }}
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'''Structural studies on delta3-delta2-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily'''
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===Structural studies on delta3-delta2-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily===
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==Overview==
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Subunits of the enzymes in the crotonase superfamily form tight trimeric disks. In most members of this protein superfamily these disks assemble further into hexamers. Here we report on the 2.1 A structure of a tight hexameric crystal form of the yeast peroxisomal delta(3)-delta(2)-enoyl-CoA isomerase (Eci1p). A comparison of this structure to a previously solved crystal form of Eci1p and other structures of this superfamily shows that there is much variability with respect to the relative distance between the disks and their relative orientations. In particular helices H2 and H9 are involved in the inter-trimer contacts and there are considerable structural differences in these helices in this superfamily. Helices H2 and H9 are near the catalytic cavity and it is postulated that the observed structural variability of these helices, stabilized by the different modes of assembly, has allowed the evolution of the wide range of substrate and catalytic specificity within this enzyme superfamily.
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The line below this paragraph, {{ABSTRACT_PUBMED_14741345}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14741345 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14741345}}
==About this Structure==
==About this Structure==
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[[Category: Beta-beta-alpha spiral fold]]
[[Category: Beta-beta-alpha spiral fold]]
[[Category: Inter-trimer contact]]
[[Category: Inter-trimer contact]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:09:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:10:45 2008''

Revision as of 09:10, 28 July 2008

Image:1pjh.png

Template:STRUCTURE 1pjh

Structural studies on delta3-delta2-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily

Template:ABSTRACT PUBMED 14741345

About this Structure

1PJH is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural studies on delta(3)-delta(2)-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily., Mursula AM, Hiltunen JK, Wierenga RK, FEBS Lett. 2004 Jan 16;557(1-3):81-7. PMID:14741345

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