1z4u

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[[Image:1z4u.gif|left|200px]]
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{{Seed}}
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[[Image:1z4u.png|left|200px]]
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{{STRUCTURE_1z4u| PDB=1z4u | SCENE= }}
{{STRUCTURE_1z4u| PDB=1z4u | SCENE= }}
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'''hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585'''
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===hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585===
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==Overview==
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A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
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(as it appears on PubMed at http://www.pubmed.gov), where 15911260 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15911260}}
==About this Structure==
==About this Structure==
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[[Category: Polymerase]]
[[Category: Polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:10:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:11:18 2008''

Revision as of 09:11, 28 July 2008

Image:1z4u.png

Template:STRUCTURE 1z4u

hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585

Template:ABSTRACT PUBMED 15911260

About this Structure

Full crystallographic information is available from OCA.

Reference

Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:15911260

Page seeded by OCA on Mon Jul 28 12:11:18 2008

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