1yd9

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[[Image:1yd9.gif|left|200px]]
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{{STRUCTURE_1yd9| PDB=1yd9 | SCENE= }}
{{STRUCTURE_1yd9| PDB=1yd9 | SCENE= }}
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'''1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.'''
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===1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.===
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==Overview==
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macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 16107708 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16107708}}
==About this Structure==
==About this Structure==
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[[Category: Alpha-beta structure]]
[[Category: Alpha-beta structure]]
[[Category: Macro-domain]]
[[Category: Macro-domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:10:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:11:26 2008''

Revision as of 09:11, 28 July 2008

Image:1yd9.png

Template:STRUCTURE 1yd9

1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.

Template:ABSTRACT PUBMED 16107708

About this Structure

1YD9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural characterization of the histone variant macroH2A., Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K, Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:16107708

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