2bme

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{{STRUCTURE_2bme| PDB=2bme | SCENE= }}
{{STRUCTURE_2bme| PDB=2bme | SCENE= }}
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'''HIGH RESOLUTION STRUCTURE OF GPPNHP-BOUND HUMAN RAB4A'''
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===HIGH RESOLUTION STRUCTURE OF GPPNHP-BOUND HUMAN RAB4A===
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==Overview==
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The Ras-related human GTPase Rab4a is involved in the regulation of endocytosis through the sorting and recycling of early endosomes. Towards further insight, we have determined the three-dimensional crystal structure of human Rab4a in its GppNHp-bound state to 1.6 Angstroms resolution and in its GDP-bound state to 1.8 Angstroms resolution, respectively. Despite the similarity of the overall structure with other Rab proteins, Rab4a displays significant differences. The structures are discussed with respect to the recently determined structure of human Rab5a and its complex with the Rab5-binding domain of the bivalent effector Rabaptin-5. The Rab4 specific residue His39 modulates the nucleotide binding pocket giving rise to a reduced rate for nucleotide hydrolysis and exchange. In comparison to Rab5, Rab4a has a different GDP-bound conformation within switch 1 region and displays shifts in position and orientation of the hydrophobic triad. The observed differences at the S2-L3-S3 region represent a new example of structural plasticity among Rab proteins and may provide a structural basis to understand the differential binding of similar effector proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 15907487 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15907487}}
==About this Structure==
==About this Structure==
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[[Category: Transport]]
[[Category: Transport]]
[[Category: Vesicular transport]]
[[Category: Vesicular transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:29:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:11:37 2008''

Revision as of 09:11, 28 July 2008

Image:2bme.png

Template:STRUCTURE 2bme

HIGH RESOLUTION STRUCTURE OF GPPNHP-BOUND HUMAN RAB4A

Template:ABSTRACT PUBMED 15907487

About this Structure

2BME is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of human Rab4a in its active and inactive conformations., Huber SK, Scheidig AJ, FEBS Lett. 2005 May 23;579(13):2821-9. Epub 2005 Apr 25. PMID:15907487

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