2ogb

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{{STRUCTURE_2ogb| PDB=2ogb | SCENE= }}
{{STRUCTURE_2ogb| PDB=2ogb | SCENE= }}
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'''Crystal structure of the C-terminal domain of mouse Nrdp1'''
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===Crystal structure of the C-terminal domain of mouse Nrdp1===
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==Overview==
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The E3 ubiquitin ligase neuregulin receptor degrading protein 1 (Nrdp1) mediates the ligand-independent degradation of the epidermal growth factor receptor family member ErbB3/HER3. By regulating cellular levels of ErbB3, Nrdp1 influences ErbB3-mediated signaling, which is essential for normal vertebrate development. Nrdp1 belongs to the tripartite or RBCC (RING, B-box, coiled-coil) family of ubiquitin ligases in which the RING domain is responsible for ubiquitin ligation and a variable C-terminal region mediates substrate recognition. We report here the 1.95 A crystal structure of the C-terminal domain of Nrdp1 and show that this domain is sufficient to mediate ErbB3 binding. Furthermore, we have used site-directed mutagenesis to map regions of the Nrdp1 surface that are important for interacting with ErbB3 and mediating its degradation in transfected cells. The ErbB3-binding site localizes to a region of Nrdp1 that is conserved from invertebrates to vertebrates, in contrast to ErbB3, which is only found in vertebrates. This observation suggests that Nrdp1 uses a common binding site to recognize its targets in different species.
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(as it appears on PubMed at http://www.pubmed.gov), where 17384230 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17384230}}
==About this Structure==
==About this Structure==
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[[Category: E3 ubiquitin ligase]]
[[Category: E3 ubiquitin ligase]]
[[Category: Receptor-binding region]]
[[Category: Receptor-binding region]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:51:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:14:26 2008''

Revision as of 09:14, 28 July 2008

Image:2ogb.png

Template:STRUCTURE 2ogb

Crystal structure of the C-terminal domain of mouse Nrdp1

Template:ABSTRACT PUBMED 17384230

About this Structure

2OGB is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3., Bouyain S, Leahy DJ, Protein Sci. 2007 Apr;16(4):654-61. PMID:17384230

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