1z23

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[[Image:1z23.gif|left|200px]]
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{{Seed}}
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[[Image:1z23.png|left|200px]]
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{{STRUCTURE_1z23| PDB=1z23 | SCENE= }}
{{STRUCTURE_1z23| PDB=1z23 | SCENE= }}
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'''The serine-rich domain from Crk-associated substrate (p130Cas)'''
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===The serine-rich domain from Crk-associated substrate (p130Cas)===
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==Overview==
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p130(cas) (Crk-associated substrate) is a docking protein that is involved in assembly of focal adhesions and concomitant cellular signaling. It plays a role in physiological regulation of cell adhesion, migration, survival, and proliferation, as well as in oncogenic transformation. The molecule consists of multiple protein-protein interaction motifs, including a serine-rich region that is positioned between Crk and Src-binding sites. This study reports the first structure of a functional domain of Cas. The solution structure of the serine-rich region has been determined by NMR spectroscopy, demonstrating that this is a stable domain that folds as a four-helix bundle, a protein-interaction motif. The serine-rich region bears strong structural similarity to four-helix bundles found in other adhesion components like focal adhesion kinase, alpha-catenin, or vinculin. Potential sites for phosphorylation and interaction with the 14-3-3 family of cellular regulators are identified in the domain and characterized by site-directed mutagenesis and binding assays. Mapping the degree of amino acid conservation onto the molecular surface reveals a patch of invariant residues near the C terminus of the bundle, which may represent a previously unidentified site for protein interaction.
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The line below this paragraph, {{ABSTRACT_PUBMED_15795225}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15795225 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15795225}}
==About this Structure==
==About this Structure==
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1Z23 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z23 OCA].
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1Z23 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z23 OCA].
==Reference==
==Reference==
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[[Category: Vuori, K.]]
[[Category: Vuori, K.]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:05:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:15:47 2008''

Revision as of 09:15, 28 July 2008

Image:1z23.png

Template:STRUCTURE 1z23

The serine-rich domain from Crk-associated substrate (p130Cas)

Template:ABSTRACT PUBMED 15795225

About this Structure

1Z23 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle., Briknarova K, Nasertorabi F, Havert ML, Eggleston E, Hoyt DW, Li C, Olson AJ, Vuori K, Ely KR, J Biol Chem. 2005 Jun 10;280(23):21908-14. Epub 2005 Mar 28. PMID:15795225

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